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ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity [OE_MCF7]

GSE242540 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/05/23 Platform GPL30173
Summary
Tumor heterogeneity complicates patient treatment and can be due to transitioning of cancer cells across phenotypic cell states. This process is associated with the acquisition of independence from an oncogenic driver, such as the estrogen receptor (ER) in breast cancer, resulting in tumor progression, therapeutic failure and metastatic spread. Here we identify the transcription factor ONECUT2 (OC2) as a lineage plasticity regulator of breast cancer (BC) that suppresses the estrogen axis and promotes luminal to basal transition. OC2 is highly expressed in a substantial subset of hormone receptor negative human BC tumors and is associated with poor clinical outcome, lymph node metastasis and heightened clinical stage. We also show that OC2 is required for cell growth and survival in metastatic BC models and that it can be targeted with a small molecule inhibitor providing a novel therapeutic strategy for patients with OC2 active tumors.
Published in
ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity
Zamora I, Gutiérrez M, Pascual A et al. · Cellular oncology (Dordrecht, Netherlands) 2025 · PMID 38819630 · doi:10.1007/s13402-024-00957-3
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Also filed as BioProject PRJNA1013898 and SRA study SRP459052. Searching any of these in the dataset finder brings you back here.

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