NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 44 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Prostate cancerThis series is part of our curated briefing on it.
- Samples
- 44 samples: 16 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesisbioRxiv : the preprint server for biology · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE242737_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1014431 and SRA study SRP459323. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 16 replicated groups read from 44 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7767862 LNCaP_AR_NSD2KO
- GSM7767863 LNCaP_AR_NSD2WT
- GSM7767864 LNCaP_FOXA1_NSD2KO
- GSM7767865 LNCaP_FOXA1_NSD2WT
- GSM7767866 LNCaP_H3k27Ac_NSD2KO
- GSM7767867 LNCaP_H3k27Ac_NSD2WT
- GSM7767868 LNCaP_AR_DMSO
- GSM7767869 LNCaP_AR_LLC0150
- GSM7767870 LNCaP_FOXA1_DMSO
- GSM7767871 LNCaP_FOXA1_LLC0150
- GSM7767872 LNCaP_H3K27Ac_DMSO
- GSM7767873 LNCaP_H3K27Ac_LLC0150
- GSM7767881 LNCaP_sgNCx3_rep1 LNCaP_sgNCx3
- GSM7767882 LNCaP_sgNCx3_rep2 LNCaP_sgNCx3
- GSM7767884 LNCaP_sgNSD1_rep1 LNCaP_sgNSD1
- GSM7767885 LNCaP_sgNSD1_rep2 LNCaP_sgNSD1
- GSM7767886 LNCaP_sgNSD3_rep1 LNCaP_sgNSD3
- GSM7767888 LNCaP_sgNSD3_rep2 LNCaP_sgNSD3
- GSM7767889 VCaP_siNC_DMSO_Rep1 VCaP_siNC_DMSO
- GSM7767890 VCaP_siNC_DMSO_Rep2 VCaP_siNC_DMSO
- GSM7767892 VCaP_siNC_EPZ6438_72h_Rep1 VCaP_siNC_EPZ6438_72h
- GSM7767893 VCaP_siNC_EPZ6438_72h_Rep2 VCaP_siNC_EPZ6438_72h
- GSM7767894 VCaP_siNSD1_DMSO_Rep1 VCaP_siNSD1_DMSO
- GSM7767896 VCaP_siNSD1_DMSO_Rep2 VCaP_siNSD1_DMSO
- GSM7767897 VCaP_siNSD1and2_DMSO_Rep1 VCaP_siNSD1and2_DMSO
- GSM7767898 VCaP_siNSD1and2_DMSO_Rep2 VCaP_siNSD1and2_DMSO
- GSM7767900 VCaP_siNSD2_DMSO_Rep1 VCaP_siNSD2_DMSO
- GSM7767901 VCaP_siNSD2_DMSO_Rep2 VCaP_siNSD2_DMSO
- GSM7767902 LNCaP_DMSO_rep1 LNCaP_DMSO
- GSM7767904 LNCaP_DMSO_rep2 LNCaP_DMSO
- GSM7767905 LNCaP_LLC0150_24hr_rep1 LNCaP_LLC0150_24hr
- GSM7767906 LNCaP_LLC0150_24hr_rep2 LNCaP_LLC0150_24hr
- GSM7767908 LNCaP_NSD2_KO_DHT_12h_R1 LNCaP_NSD2_KO_DHT_12h
- GSM7767909 LNCaP_NSD2_KO_DHT_12h_R2 LNCaP_NSD2_KO_DHT_12h
- GSM7767911 LNCaP_NSD2_KO_R1 LNCaP_NSD2_KO
- GSM7767912 LNCaP_NSD2_KO_R2 LNCaP_NSD2_KO
- GSM7767913 LNCaP_NSD2_WT_DHT_12hr_R1 LNCaP_NSD2_WT_DHT_12hr
- GSM7767915 LNCaP_NSD2_WT_DHT_12hr_R2 LNCaP_NSD2_WT_DHT_12hr
- GSM7767916 LNCaP_NSD2_WT_R1 LNCaP_NSD2_WT
- GSM7767917 LNCaP_NSD2_WT_R2 LNCaP_NSD2_WT
+ 4 more — browse all 44 samples with per-sample file links →
- GSE115501 RNA sequencing on circulating tumor cells from prostate cancer patients 136 samples same disease briefing · shares prostate
- GSE222467 The RNA binding proteins LARP4A and LARP4B promote tumour growth and metastasis in prostate cancer and osteosarcoma 12 samples same disease briefing · shares prostate
- GSE300947 A novel six-biomarker panel identified from male breast cancer-associated fibroblasts demonstrates prognostic power for prostate tumors 6 samples same disease briefing · shares prostate
- GSE120181 Human prostate cancer cell line, 22Rv1: Control vs. luteolin treatment 2 samples same disease briefing · shares prostate
- GSE71008 Plasma extracellular RNA profiles in healthy and cancer patients 192 samples same disease briefing
- GSE242541 ONECUT2 is a druggable driver of luminal to basal breast cancer plasticity 12 samples same disease briefing
- GSE242735 NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis [RNA-seq] 32 samples shares foxa1, nsd2, neo-enhanceosome, tumorigenesis, requisite, promoting, prostate, subunit
- GSE242734 NSD2 is a requisite subunit of the AR/FOXA1 neo-enhanceosome in promoting prostate tumorigenesis [ChIP-seq] 12 samples shares foxa1, nsd2, neo-enhanceosome, tumorigenesis, requisite, promoting, prostate, subunit
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.