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PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function

GSE242798 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/09/07 Platform GPL24676
Summary
The function and regulation of PD-1/PD-L1 axis have been widely studied for immune escape of various cancer cells. However, the underlying function and regulation of PD-L2 remain poorly to be understood. We demonstrate that PD-L2 is majorly secreted and expressed on exosomes with surface localization by tumor cell. In order to investigate the function of TDE-PD-L2 in the regulation of lymphocytes, we explored the expression profiles of TDE-PD-L2 on lymphocytes of PBMC using RNA-seq.
Published in
PD-L2 of tumor-derived exosomes mediates the immune escape of cancer cells via the impaired T cell function
Liu T, Cheng S, Peng B et al. · Cell death & disease 2024 · PMID 39511147 · doi:10.1038/s41419-024-07191-7
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Also filed as BioProject PRJNA1014764 and SRA study SRP459484. Searching any of these in the dataset finder brings you back here.

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