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Tumor-intrinsic P2RY6 signaling promotes prostaglandin E2 production to suppress anti-tumor immunity [ATAC]

GSE242928 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 4 samples Submitted 2024/09/17 Platform GPL17021
Summary
Our RNAseq results showed that P2RY6 induced the expression of Ptgs1 and Ptgs2 in MC38 cells. To confirm whether P2RY6 increases the opening of cis-regulatory elements to promote Ptgs1/2 transcription, we performed Assay for Transposase-Accessible Chromatin using sequencing (ATAC-seq) to determain the chromatin accessibility across the genome in MC38 cells with or without P2RY6 expression.
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Also filed as BioProject PRJNA1015542 and SRA study SRP459869. Searching any of these in the dataset finder brings you back here.

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