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Single-cell RNA sequencing reveals the impact of CD34+ cells during heart failure in the hypertrophic heart with hyperlipidemia

GSE243389 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/08/17 Platform GPL24247
Summary
Hyperlipidemia and hypertension might play a role in cardiac fibrosis, in which a heterogeneous population of fibroblasts seems important. However, it is unknown whether CD34+ cells are involved in the pathogenesis of cardiac fibrosis. This study aimed to investigate the mechanism of CD34+ cell differentiation in cardiac fibrosis during hyperlipidemia. By analyzing the transcriptomes of single cells from the Cd34-CreERT2;R26-tdTomato&ApoE-/- heart, we also demonstrated the dynamics of cell landscape during cardiac fibrosis in the hypertrophic heart with hyperlipidemia.
Published in
Altered lipid metabolism promoting cardiac fibrosis is mediated by CD34(+) cell-derived FABP4(+) fibroblasts
Du L, Wang X, Guo Y et al. · Experimental & molecular medicine 2024 · PMID 39198543 · doi:10.1038/s12276-024-01309-9
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Also filed as BioProject PRJNA1018247 and SRA study SRP461276. Searching any of these in the dataset finder brings you back here.

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