SRRM2 splicing factor modulates cell fate in early development
RNA-seq (gene expression) · mouse · 22 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 22 samples: 6 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- SRRM2 splicing factor modulates cell fate in early developmentBiology open · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243433_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1018485 and SRA study SRP461558. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 22 samples.
How we read this: 6 replicated groups read from 22 sample titles; they account for 22 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7785540 mESC WT Replicate 1 mESC WT
- GSM7785541 mESC WT Replicate 2 mESC WT
- GSM7785542 mESC Srrm2 hKO Replicate 1 mESC Srrm2 hKO
- GSM7785543 mESC Srrm2 hKO Replicate 2 mESC Srrm2 hKO
- GSM7785558 mESC Control 24h Replicate 1 mESC Control 24h
- GSM7785559 mESC Control 24h Replicate 2 mESC Control 24h
- GSM7785560 mESC Control 24h Replicate 3 mESC Control 24h
- GSM7785561 mESC Control 72h Replicate 1 mESC Control 72h
- GSM7785562 mESC Control 72h Replicate 2 mESC Control 72h
- GSM7785563 mESC Control 72h Replicate 3 mESC Control 72h
- GSM7785564 mESC Srrm2 KD 24h Replicate 1 mESC Srrm2 KD 24h
- GSM7785565 mESC Srrm2 KD 24h Replicate 2 mESC Srrm2 KD 24h
- GSM7785566 mESC Srrm2 KD 24h Replicate 3 mESC Srrm2 KD 24h
- GSM7785567 mESC Srrm2 KD 72h Replicate 1 mESC Srrm2 KD 72h
- GSM7785568 mESC Srrm2 KD 72h Replicate 2 mESC Srrm2 KD 72h
- GSM7785569 mESC Srrm2 KD 72h Replicate 3 mESC Srrm2 KD 72h
- GSM7785570 mESC WT Replicate 1 mESC WT
- GSM7785571 mESC WT Replicate 2 mESC WT
- GSM7785572 mESC WT Replicate 3 mESC WT
- GSM7785573 mESC Srrm2 hKO Replicate 1 mESC Srrm2 hKO
- GSM7785574 mESC Srrm2 hKO Replicate 2 mESC Srrm2 hKO
- GSM7785575 mESC Srrm2 hKO Replicate 3 mESC Srrm2 hKO
- GSE299937 Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia 180 samples shares srrm2, splicing
- GSE286046 Asymmetric Histone Inheritance Regulates Differential Transcription Re-initiation and Cell Fate Decisions in Mouse Olfactory Horizontal Basal Cells 96 samples shares factor, fate
- GSE264153 TATA-binding Associated Factors have distinct roles during early mammalian development 57 samples shares factor, early
- GSE336247 Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing II 36 samples shares modulates, splicing
- GSE283382 N6-methyladenosine modulate second cell fate decision by enhancing mRNA stability of pivotal transcription factors during primitive endoderm development [TBLC_RNAseq] 98 samples shares factor, fate
- GSE287133 Cardiac fibroblast deletion of PTBP1 modulates the profibrotic response by alternative splicing. 12 samples shares modulates, splicing
- GSE302791 Targeted CRISPR-Cas9 screening identifies core transcription factors controlling murine haemato-endothelial fate commitment [RNA-seq] 12 samples shares factor, fate
- GSE297451 Temporal and Context-Dependent Requirements for the Transcription Factor Foxp3 in Regulatory T Cell Development and Maintenance [RNA-seq] 70 samples shares factor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.