GEO series
Srrm2 haploinsufficiency drives SynGAP-γ reduction, Agap3 mis-splicing, and oligodendrocyte deficits in a genetic mouse model of schizophrenia
GSE299937
Mus musculus
Expression profiling by high throughput sequencing
180 samples
2026/04/14
GPL24247
Summary
To investigate the effects of loss of function of SRRM2, a risk gene for schizophrenia and developmental delay/intellectual disability (DD/ID), we performed bulk RNA sequencing of eight brain regions at 1 and 3 months of age. We also performed single-nucleus RNA sequencing of the prefrontal cortex and striatum at 1 month of age. Both experiments compared heterozygous Srrm2 mutant mice (Srrm2+/−) with wild-type littermate controls.
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Paper (PMID 42189682) ↗
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