The effect RARG fusion genes or PML-RARA overexpression in human CD34+ cells on the gene expression.
RNA-seq (gene expression) · human · 14 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 14 samples: 7 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CPSF6-RARγ interacts with histone deacetylase 3 to promote myeloid transformation in RARG-fusion acute myeloid leukemiaNature communications · 2025
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243437_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1018496 and SRA study SRP461461. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 14 samples.
How we read this: 7 replicated groups read from 14 sample titles; they account for 14 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7785605 CON-1 CON
- GSM7785606 CON-2 CON
- GSM7785607 CPSF6-RARG-1 CPSF6-RARG
- GSM7785608 CPSF6-RARG-2 CPSF6-RARG
- GSM7785609 HNRNPC-RARG-1 HNRNPC-RARG
- GSM7785610 HNRNPC-RARG-2 HNRNPC-RARG
- GSM7785611 PML-RARG-1 PML-RARG
- GSM7785612 PML-RARG-2 PML-RARG
- GSM7785613 NUP98-RARG-1 NUP98-RARG
- GSM7785614 NUP98-RARG-2 NUP98-RARG
- GSM7785615 NPM1-RARG-1 NPM1-RARG
- GSM7785616 NPM1-RARG-2 NPM1-RARG
- GSM7785617 PML-RARA-1 PML-RARA
- GSM7785618 PML-RARA-2 PML-RARA
- GSE275303 Identifying RARG fusions or PML-RARA binding genes or analysis the epigenetic changes (H3K27ac, H3K4me1, and H3K4me3) in hCD34+ cells overexpressing CPSF6::RARG and NUP98::RARG. 34 samples shares pml-rara, rarg, cd34, fusion
- GSE229196 Effect of HES6 knockdown on gene expression in vitro differentiated megakaryocytes, erythroblasts and precursor cells, cultured from CB CD34+ HSPCs. 36 samples shares cd34
- GSE215045 Transcriptional profiling by 3' digital gene expression of human CD34+ HSPCs isolated from the umbilical cord blood 96 samples shares cd34
- GSE248671 Gene expression analysis of human sickle cell disease (SCD) and healthy donor (HD) CD34+ hematopoietic stem/progenitor cells (HSPCs) treated with CRISPR/Cas9 targeting the HBG promoters or untreated samples 24 samples shares cd34
- GSE57561 RNA expression profiling of human mPB or CB-derived CD34+ cells treated with UM171 at different doses 18 samples shares cd34
- GSE324988 Effect of BHLHE40 silencing using short-hair pin RNA on CD34+ cells isolated from human cord blood, during TGF-B1 depedent Langerhans cell differentiation 12 samples shares cd34
- GSE283710 RSK1 is an exploitable dependency in myeloid malignancies [CD34RNAseq] 90 samples shares cd34
- GSE300707 Characterization of human CD34+ HSPC-derived neutrophils with limited myeloid-derived immunosuppressive cell activity 46 samples shares cd34
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.