Effect of BHLHE40 silencing using short-hair pin RNA on CD34+ cells isolated from human cord blood, during TGF-B1 depedent Langerhans cell differentiation
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 2 × A vs 2 × B vs 2 × DGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- BHLHE40/DEC1 programs epidermal Langerhans cell identityThe Journal of investigative dermatology · 2026
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE324988_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1438183 and SRA study SRP684120. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 6 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 6 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM9590029 A0KD
- GSM9590030 A24KD
- GSM9590031 A0 A
- GSM9590032 A24 A
- GSM9590033 B0KD
- GSM9590034 B24KD
- GSM9590035 B0 B
- GSM9590036 B24 B
- GSM9590037 D0KD
- GSM9590038 D24KD
- GSM9590039 D0 D
- GSM9590040 D24 D
- GSE215045 Transcriptional profiling by 3' digital gene expression of human CD34+ HSPCs isolated from the umbilical cord blood 96 samples shares cd34, isolated
- GSE283710 RSK1 is an exploitable dependency in myeloid malignancies [CD34RNAseq] 90 samples shares cd34
- GSE300707 Characterization of human CD34+ HSPC-derived neutrophils with limited myeloid-derived immunosuppressive cell activity 46 samples shares cd34
- GSE229196 Effect of HES6 knockdown on gene expression in vitro differentiated megakaryocytes, erythroblasts and precursor cells, cultured from CB CD34+ HSPCs. 36 samples shares cd34
- GSE305979 Perturbational single-cell RNA-seq time course of CD34+ HSPC megakaryocyte differentiation with CMO multiplexing (Days 0–7, 1 uM compounds) 34 samples shares cd34
- GSE297682 BRRIAR lncRNA alters breast cancer risk by modulating interferon signaling in cis and in trans through BHLHE40 and RIG-I [RNA-Seq] 27 samples shares bhlhe40
- GSE57299 Transcriptome data of CD34+ human cord blood-derived cell treated with UM171, SR1 or both 25 samples shares cd34
- GSE328951 The embryonic origins of site-specific arthritis; Bulk RNA sequencing of CD34+(Pi16+) fibroblasts stimulated with TNF and IL1b. 24 samples shares cd34
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.