GEO series
SORBS2 regulates integrin-cytoskeleton interactions and extracellular matrix composition in heart failure
GSE243463
Mus musculus
Expression profiling by high throughput sequencing
16 samples
2025/03/17
GPL30172
Summary
Heart failure is associated with high mortality rates and reduced quality of life. Because of the tight connection between Nppa expression and cardiomyocyte stress, we first determined NPPA correlated genes during heart failure. In this study, we identify SORBS2 as conserved NPPA correlated gene and detail its molecular function and association with heart failure. We used RNA-sequencing on murine whole heart tissue to study the effect of cardiomyocyte-specific genetic loss of Sorbs2 in adult mice in a healthy situation and heart failure model.
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Paper (PMID 39957251) ↗
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