TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity
ChIP-seq / ATAC-seq (genome binding and open chromatin) · mouse · 65 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Mus musculus (mouse)
- Samples
- 65 samples: 13 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activityBreast cancer research : BCR · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE243511_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1018821 and SRA study SRP461614. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 49 samples.
How we read this: 13 replicated groups read from 65 sample titles; they account for 49 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7789669 shRen basal rep1 shRen basal
- GSM7789670 shRen luminal rep1 shRen luminal
- GSM7789671 shTRPS1.34 basal rep1 shTRPS1.34 basal
- GSM7789672 shTRPS1.34 luminal rep1 shTRPS1.34 luminal
- GSM7789673 shRen basal rep2 shRen basal
- GSM7789674 shRen luminal rep2 shRen luminal
- GSM7789675 shTRPS1.32 basal rep1
- GSM7789676 shTRPS1.32 luminal rep1
- GSM7789677 shTRPS1.34 basal rep2 shTRPS1.34 basal
- GSM7789678 shTRPS1.34 luminal rep2 shTRPS1.34 luminal
- GSM7789679 shRen basal rep3 shRen basal
- GSM7789680 shRen luminal rep3 shRen luminal
- GSM7789681 shRen basal rep4 shRen basal
- GSM7789682 shRen luminal rep4 shRen luminal
- GSM7789683 shRen basal rep5 shRen basal
- GSM7789684 shRen luminal rep5 shRen luminal
- GSM7789685 shRen basal rep6 shRen basal
- GSM7789686 shRen luminal rep6 shRen luminal
- GSM7789687 luminal wild type rep1 luminal wild type
- GSM7789688 basal wild type rep1 basal wild type
- GSM7789689 luminal wild type rep2 luminal wild type
- GSM7789690 basal wild type rep2 basal wild type
- GSM7789691 luminal wild type rep3 luminal wild type
- GSM7789692 basal wild type rep3 basal wild type
- GSM7789693 luminal wild type rep4 luminal wild type
- GSM7789694 basal wild type rep4 basal wild type
- GSM7789695 luminal wild type rep5 luminal wild type
- GSM7789696 basal wild type rep5 basal wild type
- GSM7789697 shRen rep1 shRen
- GSM7789698 shRen rep2 shRen
- GSM7789699 shRen rep3 shRen
- GSM7789700 shRen rep4 shRen
- GSM7789701 shRen rep5 shRen
- GSM7789702 shTRPS1.32 rep1 shTRPS1.32
- GSM7789703 shTRPS1.32 rep2 shTRPS1.32
- GSM7789704 shTRPS1.34 rep1 shTRPS1.34
- GSM7789705 shTRPS1.34 rep2 shTRPS1.34
- GSM7789706 shTRPS1.34 rep3 shTRPS1.34
- GSM7789707 shTRPS1.34 rep4 shTRPS1.34
- GSM7789708 luminal progenitor type rep1 luminal progenitor type
+ 25 more — browse all 65 samples with per-sample file links →
- GSE243504 TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity [01a_bulk_rna_seq_PCX_Cre_shTRPS1] 18 samples shares trps1, mrtf, srf, progenitors, repressing, maintains, activity, luminal
- GSE243508 TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity [02_citeseq_shTRPS1_mmg] 12 samples shares trps1, mrtf, srf, progenitors, repressing, maintains, activity, luminal
- GSE243506 TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity [01c_bulk_rna_seq_K8-CreER_shTRPS1] 11 samples shares trps1, mrtf, srf, progenitors, repressing, maintains, activity, luminal
- GSE243505 TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity [01b_bulk_rna_seq_luminal_vs_basal] 10 samples shares trps1, mrtf, srf, progenitors, repressing, maintains, activity, luminal
- GSE285078 MRTFA-SRF driven gene expression promotes cellular stiffness by controlling cytoplasmic Ca2+ and K+ levels in cancer cells II 36 samples shares mrtf, srf
- GSE298922 Inactivation of the SRF cofactors Mrtfa and Mrtfb in MEFs results in proliferation defects and reduced expression of cytoskeletal and cell cycle progression genes 24 samples shares mrtf, srf
- GSE273414 MRTFA-SRF driven gene expression promotes cellular stiffness by controlling cytoplasmic Ca2+ and K+ levels in cancer cells 18 samples shares mrtf, srf
- GSE300990 Serum Response Factor (SRF) drives actin cytoskeletal organization in adipocytes to support adaptive hypertrophic expansion and tissue remodeling during obesity 30 samples shares srf
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.