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Development of a new model of Parkinson´s disease

GSE243520 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2025/03/09 Platform GPL17021
Summary
To get insight the molecular mechanism underlying neuronal loss in Parkinson´s disease. We performed gene expression profiling analysis using data obtained from RNA-seq of midbrain of mice injected with an AAV control or an AAV expressing human tyrosinase that induces neuromelanin accumulation and subsequent neuronal loss.
Published in
FKBP51 inhibition ameliorates neurodegeneration and motor dysfunction in the neuromelanin-SNCA mouse model of Parkinson's disease
Garcia-Gomara M, Legarra-Marcos N, Serena M et al. · Molecular therapy : the journal of the American Society of Gene Therapy 2025 · PMID 39905728 · doi:10.1016/j.ymthe.2025.01.049
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Also filed as BioProject PRJNA1018840 and SRA study SRP461672. Searching any of these in the dataset finder brings you back here.

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