GEO series
Small molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation
GSE243692
Mus musculus
Expression profiling by high throughput sequencing
90 samples
2024/06/27
GPL19057
Summary
BRD5075 is a positive allosteric modulator of GPR65. Activity has been demonstrated by cAMP production in HeLa cells overexpessing GPR65 and target engagment has been confirmed. BRD5075 also decreases TNF-a secretion by GPR65 WT BMDCs. Goal is to identify differentially expressed genes in response to this GPR65 PAM
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Paper (PMID 39028811) ↗
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