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Effects of methionine, tryptophan, and niacin deficient diets on gene expression in intestinal cells in the DSS drinking IBD mouse model.

GSE239475 Mus musculus Expression profiling by high throughput sequencing 9 samples Submitted 2024/03/18 Platform GPL28457
Summary
Inflammatory bowel disease (IBD) is one of the intractable diseases. Nutritional components associated with IBD have been identified, and it is known that excessive methionine intake exacerbates inflammation and that tryptophan metabolism is involved in inflammation. In this study, we examined how temporary methionine, tryptophan, and niacin deficiencies alter gene expression in the intestinal cells of a dextran sulfate sodium (DSS)-fed IBD mouse model. The results showed that feeding amino acid deficient diets increased the expression of serine proteases and fat metabolizing enzymes. Amino acid deficiency also activated one-carbon metabolism and the PPAR pathway. These results suggest that temporary amino acid deficiency may be useful to enhance the antioxidant activity of the host.
Published in
Fat and proteolysis due to methionine, tryptophan, and niacin deficiency leads to alterations in gut microbiota and immune modulation in inflammatory bowel disease
Hara T, Meng S, Motooka D et al. · Cancer science 2024 · PMID 38679799 · doi:10.1111/cas.16153
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Also filed as BioProject PRJNA999353 and SRA study SRP451869. Searching any of these in the dataset finder brings you back here.

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