← BioTransfer GEO Dataset Finder
GEO series

A role of p53 in mediating epigenetic stress (RNA-Seq)

GSE243784 Homo sapiens Expression profiling by high throughput sequencing 9 samples Submitted 2025/08/27 Platform GPL18573
Summary
5-Azacytidine (Aza) and 5-Aza-2'-deoxycytidine (Dac) are the only epigenome modifying drugs in widespread clinical use, and are some of the primary therapeutics for Acute Myeloid Leukaemia treatment. The two are frequently used interchangeably, surprisingly as their selectivity of de-methylation is unique from the other, with to date no identified predictors of response or known biomarkers to indicate drug preference. Using these drugs to induce de-methylating conditions, we combine data from DRIPc-Seq, Immunostaining, RNA-Seq and Mass spectrometry with epigenetic analysis to uncover unique cellular responses following Aza and Dac treatment.
This dataset
Download

Direct links to NCBI, no account and no request form: the whole study as GSE243784_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 9 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1019811 and SRA study SRP462569. Searching any of these in the dataset finder brings you back here.

Samples in this study

The sample list for this study is not cached yet. Press Sort into groups and it will be fetched from NCBI.

+ 9 more — browse all 9 samples with per-sample file links →

Similar datasets

Search all human RNA-seq datasets in GEO →

Share this dataset

Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.