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Extracellular Granzyme B directly drives Interferon-stimulated genes expression in macrophages.

GSE244113 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2025/08/01 Platform GPL24247
Summary
Previous research indicate MIA propagates maternal inflammation to the fetal developing brain, that manifests as increased pro-inflammatory cytokines and activation of macrophages. Our data sugests that maternal Granzyme B released by aberrant decidual NK cells can reach to the fetal brain and instigate the activation of macrophages. To determine whether Gzmb can directly impact macrophages, we co-cultured murine microglial BV-2 cells with Gzmb for 20 hours, and then performed gene expression profiling analysis. We found that GzmB exposure directly induces a unique gene signature in microglia that includes the unexpected upregulation of multiple interferon-stimulated genes (ISGs).
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Also filed as BioProject PRJNA1021250 and SRA study SRP463267. Searching any of these in the dataset finder brings you back here.

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