Epigenomic Landscapes Define Differential JAK Inhibitor Sensitivity in IFN-γ-Primed Human Macrophages
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 16 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Samples
- 16 samples: 8 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Epigenomic landscapes define differential Janus kinases inhibitor sensitivity in IFN-γ-primed human macrophagesiScience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244130_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1021443 and SRA study SRP463503. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 16 samples.
How we read this: 8 replicated groups read from 16 sample titles; they account for 16 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7807700 ATAC_Resting_Ctrl_1 ATAC_Resting_Ctrl
- GSM7807701 ATAC_Resting_Ctrl_2 ATAC_Resting_Ctrl
- GSM7807702 ATAC_Resting_Tofa_1 ATAC_Resting_Tofa
- GSM7807703 ATAC_Resting_Tofa_2 ATAC_Resting_Tofa
- GSM7807704 ATAC_IFNg_Ctrl_1 ATAC_IFNg_Ctrl
- GSM7807705 ATAC_IFNg_Ctrl_2 ATAC_IFNg_Ctrl
- GSM7807706 ATAC_IFNg_Tofa_1 ATAC_IFNg_Tofa
- GSM7807707 ATAC_IFNg_Tofa_2 ATAC_IFNg_Tofa
- GSM7807708 RNA_Resting_Ctrl_1 RNA_Resting_Ctrl
- GSM7807709 RNA_Resting_Ctrl_2 RNA_Resting_Ctrl
- GSM7807710 RNA_Resting_Tofa_1 RNA_Resting_Tofa
- GSM7807711 RNA_Resting_Tofa_2 RNA_Resting_Tofa
- GSM7807712 RNA_IFNg_Ctrl_1 RNA_IFNg_Ctrl
- GSM7807713 RNA_IFNg_Ctrl_2 RNA_IFNg_Ctrl
- GSM7807714 RNA_IFNg_Tofa_1 RNA_IFNg_Tofa
- GSM7807715 RNA_IFNg_Tofa_2 RNA_IFNg_Tofa
- GSE271384 The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [ATAC-seq] 20 samples shares differential, epigenomic, landscapes
- GSE271385 The APOE isoforms differentially shape the transcriptomic and epigenomic landscapes of human microglia in a xenotransplantation model of Alzheimer’s disease [RNA-seq] 19 samples shares differential, epigenomic, landscapes
- GSE306664 Revealing differential type I and type II IFN responses in different immune cells in various human diseases by a new IFNs transcriptomic atlas 131 samples shares ifn, differential
- GSE80688 Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate for Alopecia Areata and Variants 56 samples shares jak, inhibitor
- GSE294916 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [CUT&Tag] 28 samples shares ifn, macrophages
- GSE294915 IFNγ-induced memory in human macrophages is not sustained by epigenetic changes but the durability of the cytokine itself [ATAC-Seq] 22 samples shares ifn, macrophages
- GSE296117 A single-cell RNA-seq dataset of synovial fluid from rheumatoid arthritis treated with TNF-α/JAK inhibitor 18 samples shares jak, inhibitor
- GSE316734 Characterization of sensitivity and resistance mechanisms to DHX9 inhibitor in endometrial and ovarian cancer cell lines 48 samples shares sensitivity, inhibitor
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.