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Single cell atlas of the aging mouse trachea

GSE244215 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/03/05 Platform GPL24247
Summary
The airways conduct gases to and from the gas-exchanging alveoli of the lung and are the site of age-related diseases, such as chronic obstructive pulmonary disease, asthma, and bronchogenic carcinoma. Here we set out to study the effects of aging on the cellular composition and gene expression of murine airway. We present a comprehensive single-cell RNA-sequencing atlas of tracheas from young (2 month) and aged (24 month) mice, comprising diverse populations of cells, including epithelial, endothelial, immune, fibroblast, and cartilage cells.
Published in
Airway hillocks are injury-resistant reservoirs of unique plastic stem cells
Lin B, Shah VS, Chernoff C et al. · Nature 2024 · PMID 38693267 · doi:10.1038/s41586-024-07377-1
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Direct links to NCBI, no account and no request form: the whole study as GSE244215_RAW.tar, processed values as the series matrix, the supplementary file directory, and per-sample supplementary files for any of the 4 samples. Raw sequencing reads are also available from ENA.

Also filed as BioProject PRJNA1021685 and SRA study SRP463561. Searching any of these in the dataset finder brings you back here.

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