Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiation
RNA-seq (gene expression) · human · 48 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 48 samples: 16 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Engrailed 1 deficiency induces changes in ciliogenesis during human neuronal differentiationNeurobiology of disease · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244435_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1023165 and SRA study SRP464130. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 48 samples.
How we read this: 16 replicated groups read from 48 sample titles; they account for 48 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7816094 5-6_unstimulated_1 5-6_unstimulated
- GSM7816095 5-6_unstimulated_2 5-6_unstimulated
- GSM7816096 5-6_unstimulated_3 5-6_unstimulated
- GSM7816097 5-12_unstimulated_1 5-12_unstimulated
- GSM7816098 5-12_unstimulated_2 5-12_unstimulated
- GSM7816099 5-12_unstimulated_3 5-12_unstimulated
- GSM7816100 25-19_unstimulated_1 25-19_unstimulated
- GSM7816101 25-19_unstimulated_2 25-19_unstimulated
- GSM7816102 25-19_unstimulated_3 25-19_unstimulated
- GSM7816103 4-3_unstimulated_1 4-3_unstimulated
- GSM7816104 4-3_unstimulated_2 4-3_unstimulated
- GSM7816105 4-3_unstimulated_3 4-3_unstimulated
- GSM7816106 4-4_unstimulated_1 4-4_unstimulated
- GSM7816107 4-4_unstimulated_2 4-4_unstimulated
- GSM7816108 4-4_unstimulated_3 4-4_unstimulated
- GSM7816109 4-5_unstimulated_1 4-5_unstimulated
- GSM7816110 4-5_unstimulated_2 4-5_unstimulated
- GSM7816111 4-5_unstimulated_3 4-5_unstimulated
- GSM7816112 15-1_unstimulated_1 15-1_unstimulated
- GSM7816113 15-1_unstimulated_2 15-1_unstimulated
- GSM7816114 15-1_unstimulated_3 15-1_unstimulated
- GSM7816115 18-3_unstimulated_1 18-3_unstimulated
- GSM7816116 18-3_unstimulated_2 18-3_unstimulated
- GSM7816117 18-3_unstimulated_3 18-3_unstimulated
- GSM7816118 5-6_stimulated_1 5-6_stimulated
- GSM7816119 5-6_stimulated_2 5-6_stimulated
- GSM7816120 5-6_stimulated_3 5-6_stimulated
- GSM7816121 5-12_stimulated_1 5-12_stimulated
- GSM7816122 5-12_stimulated_2 5-12_stimulated
- GSM7816123 5-12_stimulated_3 5-12_stimulated
- GSM7816124 25-19_stimulated_1 25-19_stimulated
- GSM7816125 25-19_stimulated_2 25-19_stimulated
- GSM7816126 25-19_stimulated_3 25-19_stimulated
- GSM7816127 4-3_stimulated_1 4-3_stimulated
- GSM7816128 4-3_stimulated_2 4-3_stimulated
- GSM7816129 4-3_stimulated_3 4-3_stimulated
- GSM7816130 4-4_stimulated_1 4-4_stimulated
- GSM7816131 4-4_stimulated_2 4-4_stimulated
- GSM7816132 4-4_stimulated_3 4-4_stimulated
- GSM7816133 4-5_stimulated_1 4-5_stimulated
+ 8 more — browse all 48 samples with per-sample file links →
- GSE245323 Dynamics and consequences of widespread transcript isoform changes during neuronal differentiation [RNA-Seq] 24 samples shares neuronal, changes
- GSE307922 Destabilization of the noncanonical PRC1.1 complex via USP7 inhibition induces neuronal differentiation in neuroblastoma [RNA-Seq] 18 samples shares neuronal, induces
- GSE286949 Neuronal hyperactivity becomes mTORC1 independent due to epigenetic changes in Tuberous Sclerosis Complex [RNA-seq] 96 samples shares neuronal, changes
- GSE303648 Rb1 deficiency induces synthetic lethality with ATR and PKMYT1 co-inhibition in breast cancer 57 samples shares deficiency, induces
- GSE247623 Succinate dehydrogenase deficiency-driven succinate accumulation induces drug resistance in acute myeloid leukemia via ubiquitin-cullin regulation 18 samples shares deficiency, induces
- GSE309028 TP53 deficiency in AML induces resistance to T-cell engagers through an immunosuppressive secretome 12 samples shares deficiency, induces
- GSE241074 Anti-asthma drug Montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling 27 samples shares neuronal, induces
- GSE232669 Anti-asthma drug Montelukast induces autistic behaviors via disrupting neuronal retinoic acid signaling [RNA-seq and Ribo-seq] 18 samples shares neuronal, induces
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.