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Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance II

GSE244501 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/18 Platform GPL30172
Summary
Medullary thymic epithelial cells (mTECs) are essential for the establishment of self-tolerance in T cells. Promiscuous gene expression by a subpopulation of mTECs regulated by nuclear protein Aire contributes to the display of self-genomic products to newly generated T cells. Recent reports have highlighted additional self-antigen-displaying mTEC subpopulations; namely, Fezf2-expressing mTECs and a mosaic of self-mimetic mTECs including thymic tuft cells. In addition, a functionally different subset of mTECs produces chemokine CCL21 that attracts developing thymocytes to the medullary region. Here we report that CCL21+ mTECs and Aire+ mTECs non-redundantly cooperate to direct self-tolerance to prevent autoimmune pathology by optimizing the deletion of self-reactive T cells and the generation of regulatory T cells. We also detected a cooperation for self-tolerance between Aire and Fezf2, which unexpectedly regulates thymic tuft cells. Our results indicate an indispensable interplay among functionally diverse mTECs for the establishment of central self-tolerance.
Published in
Functionally diverse thymic medullary epithelial cells interplay to direct central tolerance
Ushio A, Matsuda-Lennikov M, Kalle-Youngoue F et al. · Cell reports 2024 · PMID 38581680 · doi:10.1016/j.celrep.2024.114072
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Also filed as BioProject PRJNA1023277 and SRA study SRP464216. Searching any of these in the dataset finder brings you back here.

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