ORAI1 inhibition as an efficient preclinical therapy for tubular aggregate myopathy and Stormorken syndrome
RNA-seq (gene expression) · mouse · 32 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 32 samples: 6 conditions, mostly with about 4 replicates eachGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- ORAI1 inhibition as an efficient preclinical therapy for tubular aggregate myopathy and Stormorken syndromeJCI insight · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE244524_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1023487 and SRA study SRP464291. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 32 samples.
How we read this: 6 replicated groups read from 32 sample titles; they account for 32 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7818625 TA muscle, WT2 TA muscle, WT
- GSM7818626 TA muscle, WT3 TA muscle, WT
- GSM7818627 TA muscle, WT4 TA muscle, WT
- GSM7818628 TA muscle, Orai1KO_1 TA muscle, Orai1KO
- GSM7818629 TA muscle, Orai1KO_2 TA muscle, Orai1KO
- GSM7818630 TA muscle, Orai1KO_3 TA muscle, Orai1KO
- GSM7818631 TA muscle, Orai1KO_4 TA muscle, Orai1KO
- GSM7818632 TA muscle, Stim1KI_1 TA muscle, Stim1KI
- GSM7818633 TA muscle, Stim1KI_2 TA muscle, Stim1KI
- GSM7818634 TA muscle, Stim1KI_3 TA muscle, Stim1KI
- GSM7818635 TA muscle, Stim1KI_4 TA muscle, Stim1KI
- GSM7818636 TA muscle, KIKO_1 TA muscle, KIKO
- GSM7818637 TA muscle, KIKO_2 TA muscle, KIKO
- GSM7818638 TA muscle, KIKO_3 TA muscle, KIKO
- GSM7818639 TA muscle, KIKO_4 TA muscle, KIKO
- GSM7818640 TA muscle, WT_5 TA muscle, WT
- GSM7818641 TA muscle, WT_6 TA muscle, WT
- GSM7818642 TA muscle, WT_7 TA muscle, WT
- GSM7818643 TA muscle, WT_8 TA muscle, WT
- GSM7818644 TA muscle, Orai1KI_1 TA muscle, Orai1KI
- GSM7818645 TA muscle, Orai1KI_3 TA muscle, Orai1KI
- GSM7818646 TA muscle, Orai1KI_4 TA muscle, Orai1KI
- GSM7818647 TA muscle, Stim1KI_5 TA muscle, Stim1KI
- GSM7818648 TA muscle, Stim1KI_6 TA muscle, Stim1KI
- GSM7818649 TA muscle, Stim1KI_7 TA muscle, Stim1KI
- GSM7818650 TA muscle, Stim1KI_8 TA muscle, Stim1KI
- GSM7818651 TA muscle, KIKI_1 TA muscle, KIKI
- GSM7818652 TA muscle, KIKI_2 TA muscle, KIKI
- GSM7818653 TA muscle, KIKI_3 TA muscle, KIKI
- GSM7818654 TA muscle, KIKI_4 TA muscle, KIKI
- GSM7818655 TA muscle, WT1 TA muscle, WT
- GSM7818656 TA muscle, Orai1KI_2 TA muscle, Orai1KI
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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.