Custom-designed lipid-based nanoparticles efficiently deliver mRNA to reverse the pathogenesis of LAL deficiency in a preclinical model
RNA-seq (gene expression) · mouse · 28 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 28 samples: 28 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE280933_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1181265 and SRA study SRP542772. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 28 sample titles: 28 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8607733 0644 LAL KO empty
- GSM8607734 0638 LAL KO empty
- GSM8607735 0634 LAL KO empty
- GSM8607736 0718 LAL KO empty
- GSM8607737 0675 LAL KO empty
- GSM8607738 0639 LAL KO empty
- GSM8607739 0635 LAL KO empty
- GSM8607740 0697 LAL KO empty
- GSM8607741 0683 LAL KO empty
- GSM8607742 0724 WT empty
- GSM8607743 0754 WT empty
- GSM8607744 0706 WT empty
- GSM8607745 0692 WT empty
- GSM8607746 0707 WT empty
- GSM8607747 0671 WT empty
- GSM8607748 0681 WT empty
- GSM8607749 0677 WT empty
- GSM8607750 0669 WT empty
- GSM8607751 0654 LAL KO hLAL mRNA
- GSM8607752 0642 LAL KO hLAL mRNA
- GSM8607753 0632 LAL KO hLAL mRNA
- GSM8607754 0708 LAL KO hLAL mRNA
- GSM8607755 0722 LAL KO hLAL mRNA
- GSM8607756 0673 LAL KO hLAL mRNA
- GSM8607757 0665 LAL KO hLAL mRNA
- GSM8607758 0629 LAL KO hLAL mRNA
- GSM8607759 0731 LAL KO hLAL mRNA
- GSM8607760 0695 LAL KO hLAL mRNA
- GSE249674 Intratumoral administration of lipid nanoparticles carrying mRNA encoding for IL-21, IL-7, and 4-1BBL induces anti-tumor immunity in preclinical tumor models. 6 samples shares nanoparticles, preclinical
- GSE181259 Idelalisib and pneumococcal infection induce distinct transcriptional responses in mouse precision-cut lung slices 40 samples shares lal
- GSE241952 Targeting LYPLAL1-mediated cGAS depalmitoylation enhances the response to anti-tumor immunotherapy 6 samples shares lal
- GSE318724 Phenylalanine Reprograms TLS Maturation and Plasma cell differentiation in MASH-HCC [scRNA-seq] 3 samples shares lal
- GSE280397 The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators 8 samples shares lal
- GSE304212 Molecular Pathogenesis of Alzheimer's Disease Onset in a Mouse Model: Effects of Cannabidiol Treatment 60 samples shares pathogenesis
- GSE255633 Region-specific pathogenesis and dissipation of intraregional heterogeneity in cerebellar neurodegeneration 49 samples shares pathogenesis
- GSE261778 Iron oxide nanoparticles inhibit tumor progression and suppress lung metastases in mouse models of breast cancer [RNA-seq] 49 samples shares nanoparticles
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.