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Knockdown of METTL14 inhibits the development of neuroblastoma

GSE244657 Homo sapiens Expression profiling by high throughput sequencing 4 samples Submitted 2024/04/02 Platform GPL24676
Summary
We investigated the mechanism by which the m6A methyltransferase METTL14 functions in neuroblastoma. To explore the downstream target genes of METTL14, we performed RNA-seq analysis and found that the expression profile of the gene was significantly altered in METTL14 knockdown SK-N-BE(2) cells. We found that overexpression of METTL14 in neuroblastoma patients was a detrimental factor.
Published in
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism
Wang J, Yin H, Li G et al. · Cell death discovery 2024 · PMID 38649363 · doi:10.1038/s41420-024-01959-8
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Also filed as BioProject PRJNA1023971 and SRA study SRP464532. Searching any of these in the dataset finder brings you back here.

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