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Spatial transcriptomics of mouse spleens during steady state and malaria infection. [d0_d7_slideseqV2]

GSE244803 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2024/07/08 Platform GPL19057
Summary
Blood-stage malaria infection induces differentiation of several effector CD4 + T subsets including Tfh and Th1 cells. The cues and microarchitectural niches required in secondary lymphoid organs for their formation were previously uncharacterised. Here we used spatial transcriptomics to characterise the microarchitecture of mouse spleen before and during malaria infection, and mapping the spatial and molecular requirements of Tfh/Th1 differentiation.
Published in
Plasmodium infection induces phenotypic, clonal, and spatial diversity among differentiating CD4(+) T cells
Williams CG, Moreira ML, Asatsuma T et al. · Cell reports 2024 · PMID 38848213 · doi:10.1016/j.celrep.2024.114317
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Also filed as BioProject PRJNA1024927 and SRA study SRP464868. Searching any of these in the dataset finder brings you back here.

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