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NSUN2 regulates thyroid cancer-associated alternative splicing switches

GSE244824 Homo sapiens Expression profiling by high throughput sequencing 8 samples Submitted 2025/03/19 Platform GPL24676
Summary
In this research, we find that both m5C deposition in splice site boundaries and in splicing, direct AS switches of specific thyroid cancer- associated transcripts. We also show that several of the AS events validated in vitro are associated with a poor overall survival rate for patients with thyroid cancer, suggesting the use of these AS events as a novel potential prognostic biomarker.
Published in
NSUN2-mediated m(5)C modification drives alternative splicing reprogramming and promotes multidrug resistance in anaplastic thyroid cancer through the NSUN2/SRSF6/UAP1 signaling axis
Hou X, Dong Q, Hao J et al. · Theranostics 2025 · PMID 40083919 · doi:10.7150/thno.104713
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Also filed as BioProject PRJNA1024963 and SRA study SRP464900. Searching any of these in the dataset finder brings you back here.

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