Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 12 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Thyroid cancerThis series is part of our curated briefing on it.
- Samples
- 12 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE294320_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1249022 and SRA study SRP578023. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8902362 Nthy, EZH1 WT, ATAC, rep1 Nthy, EZH1 WT, ATAC,
- GSM8902363 Nthy, EZH1 WT, ATAC, rep2 Nthy, EZH1 WT, ATAC,
- GSM8902364 Nthy, EZH1 Q571R, ATAC, rep1 Nthy, EZH1 Q571R, ATAC,
- GSM8902365 Nthy, EZH1 Q571R, ATAC, rep2 Nthy, EZH1 Q571R, ATAC,
- GSM9380339 Nthy, EZH2 WT, ATAC, rep1 Nthy, EZH2 WT, ATAC,
- GSM9380340 Nthy, EZH2 WT, ATAC, rep2 Nthy, EZH2 WT, ATAC,
- GSM9380341 Nthy, EZH2 Q570R, ATAC, rep1 Nthy, EZH2 Q570R, ATAC,
- GSM9380342 Nthy, EZH2 Q570R, ATAC, rep2 Nthy, EZH2 Q570R, ATAC,
- GSM9380343 Nthy, EZH1 Y727D, ATAC, rep1 Nthy, EZH1 Y727D, ATAC,
- GSM9380344 Nthy, EZH1 Y727D, ATAC, rep2 Nthy, EZH1 Y727D, ATAC,
- GSM9380345 Nthy, EZH1 Q571R;Y727D, ATAC, rep1 Nthy, EZH1 Q571R;Y727D,…
- GSM9380346 Nthy, EZH1 Q571R;Y727D, ATAC, rep2 Nthy, EZH1 Q571R;Y727D,…
- GSE294323 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin 18 samples same disease briefing · shares h3k27me3, q571r, ezh1, cancer-associated, compaction, chromatin, mutation, invasion
- GSE294321 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin 16 samples same disease briefing · shares h3k27me3, q571r, ezh1, cancer-associated, compaction, chromatin, mutation, invasion
- GSE294325 Thyroid cancer-associated EZH1 Q571R mutation drives chromatin compaction and H3K27me3 invasion into active chromatin 18 samples same disease briefing · shares h3k27me3, q571r, ezh1, cancer-associated, compaction, chromatin, mutation, invasion
- GSE317520 Mitochondrial DNA Mutations Drive Tumor Heterogeneity in Papillary Thyroid Carcinoma 92 samples same disease briefing · shares mutation
- GSE244824 NSUN2 regulates thyroid cancer-associated alternative splicing switches 8 samples same disease briefing · shares cancer-associated
- GSE310793 PRECISE: A prognostic thyroid follicular-cell derived gene signature for papillary thyroid carcinoma 109 samples same disease briefing
- GSE33630 Normal thyrocytes vs papillary vs anaplastic thyroid carcinomas 105 samples same disease briefing
- GSE60542 Revisiting the transcriptional analysis of primary tumors and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer 92 samples same disease briefing
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.