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Hepatic stellate cell-derived thrombospondin-2 as a novel therapeutic target for liver fibrosis

GSE245857 Mus musculus Expression profiling by high throughput sequencing 8 samples Submitted 2026/04/01 Platform GPL28330Platform GPL17021
Summary
The in vivo effects of silencing Thbs2 in hepatic stellate cells (HSCs) were examined using an adeno-associated virus vector (serotype 6, AAV6) containing short hairpin RNAs (shRNAs) targeting Thbs2, under the regulatory control of cytomegalovirus (CMV) or smooth muscle α-actin (αSMA) promoter, in carbon tetrachloride (CCl4) induced liver fibrosis mouse models. Bulk RNA-seq of liver tissues from AAV6-CMV-shThbs2 mice or AAV6-αSMA mice and their controls was performed.
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Also filed as BioProject PRJNA1030285 and SRA study SRP467505. Searching any of these in the dataset finder brings you back here.

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