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PD-L1 regulation of colonic inflammation and colorectal cancerdevelopment

GSE246038 Mus musculus Expression profiling by high throughput sequencing 4 samples Submitted 2024/10/01 Platform GPL24247
Summary
PD-L1 acts as an immune checkpoint that inhibits T cell activation and suppresses colonic inflammation. We aimed at determine the cellular and molecular mechanisms underlying PD-L1 function in colon epithelium and colon cancer. scRNA-seq was perform to determine the gene expression profiles in epithelial cells and immune cells in the single-cell level. Tumors were induced in WT and PD-L1 KO mice. Analysis of WT and PD-L1 KO tumors revealed that loss of PD-L1 alters T cells, myeloid cells, B cells, and tumor-associated fibroblast subpopulations. Our finding determines that PD-L1 regulates multiple cellular populations to regulates host immune response and tumor development.
Published in
PD-L1 restrains PD-1(+)Nrp1(lo) Treg cells to suppress inflammation-driven colorectal tumorigenesis
Poschel DB, Klement JD, Merting AD et al. · Cell reports 2024 · PMID 39368087 · doi:10.1016/j.celrep.2024.114819
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Also filed as BioProject PRJNA1031140 and SRA study SRP467963. Searching any of these in the dataset finder brings you back here.

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