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Occupancy profiling of IRF2BP2, MYCN, AP-1 and SOX11 by CUT&Tag from Neuroblastoma cells

GSE246065 Homo sapiens Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2024/06/24 Platform GPL24676
Summary
MYCN and SOX11 are master transcription factors (TFs) in neuroblastoma by directly occupying each other's and their own super-enhancers (SEs). Additionally, Master TFs cooperatively co-occupy the same SE components, which promotes the expression of IRF2BP2 involved in cell survival. We also observed the significant enrichment of the AP-1 family at the binding sites of IRF2BP2. In the present study, CUT&Tag (Cleavage Under Targets and Tagmentation) analysis was performed to explore the target of IRF2BP2, MYCN, AP-1 and SOX11 in NB cells.
Published in
Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation
Chen Y, Zhuo R, Sun L et al. · Neuro-oncology 2024 · PMID 38864832 · doi:10.1093/neuonc/noae109
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Also filed as BioProject PRJNA1031213 and SRA study SRP467993. Searching any of these in the dataset finder brings you back here.

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