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Next Generation Sequencing Quantitative Analysis of altered expression of genes in bladder cancer derived EVs educated draining LNs

GSE246070 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/10 Platform GPL24247
Summary
Metastasis of tumors to LNs predicts disease progression and poor outcomes of patients. Recent studies revealed that tumor cells deliver EVs to particular targeted recipient cells in draining LNs and subsequently alter their gene expression patterns to create a supportive pre-metastatic niche to promote LN metastasis. Yet, the biological role and underlying mechanism of bladder cancer derived EVs (BCa derived EVs) in mediating lymphatic pre-metastatic niche formation remain unclear. The present study aim to explore the differential genes of BCa derived EVs educated draining LNs and underlying mechanism in the lymphatic pre-metastatic niche formation.
Published in
Integrin α6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151
Lin Y, Zheng H, Jia L et al. · Journal of extracellular vesicles 2024 · PMID 39329462 · doi:10.1002/jev2.12518
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Also filed as BioProject PRJNA1031224 and SRA study SRP468008. Searching any of these in the dataset finder brings you back here.

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