GEO series
Dynamic dysregulation of the transcriptome upon deletion of Mecp2 in adult mice
GSE246119
Mus musculus
Expression profiling by high throughput sequencing
144 samples
2024/12/16
GPL17021
Summary
Loss of function mutations in methyl Cpg binding protein 2 (MECP2) cause Rett syndrome. Loss of MeCP2 causes global transcriptional dysregulation, but it was unknown whether this transcriptional dysregulation was proximal to Mecp2 function. We deleted Mecp2 from adult mice and performed a time-series RNA-seq experiment to identif what transcripts were altered immediately upon loss of MeCP2.
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Paper (PMID 39689710) ↗
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