CircHIPK3 and FMRP compete for direct binding to BRCA1 mRNA controlling its protein levels and DNA damage response
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246226_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1032074 and SRA study SRP468409. Searching any of these in the dataset finder brings you back here.
The sample list for this study is not cached yet. Press Load samples and it will be fetched from NCBI.
+ 12 more — browse all 12 samples with per-sample file links →
- GSE246224 CircHIPK3 and FMRP compete for direct binding to BRCA1 mRNA controlling its protein levels and DNA damage response [RNA_pulldown] 8 samples shares circhipk3, brca1, fmrp, controlling, compete, binding, protein, direct
- GSE315381 Heterozygous BRCA1 SNPs in the DNA Binding Domain Enhance Sensitivity to PARP Inhibition in Breast Cancer Cells 3 samples shares brca1, binding
- GSE213779 Long noncoding RNA GATA2AS regulates human erythroid differentiation by controlling erythroid transcription factors binding and regulatory landscape 57 samples shares controlling, binding
- GSE262642 KCTD proteins have redundant functions in controlling cellular growth. 12 samples shares controlling, protein
- GSE308337 The C16orf87 protein is a subunit of the MIER corepressor complex controlling embryonic development and cell migration 6 samples shares controlling, protein
- GSE283869 Protein kinase A regulates ferroptosis by controlling GPX4 m6A modification through phosphorylation of ALKBH5 4 samples shares controlling, protein
- GSE292700 Molecular architecture of the tumor microenvironment caused by BRCA1 and BRCA2 somatic mutations in human lung adenocarcinoma 12 samples shares brca1
- GSE43837 A BRCA1 Deficient-Like Signature is Enriched in Breast Cancer Brain Metastases 38 samples shares brca1
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.