CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy I
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 18 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- CD4+ CAR T-cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR T-cell therapyBlood advances · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246342_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1032579 and SRA study SRP468635. Searching any of these in the dataset finder brings you back here.
Supports a case/control comparison: 14 samples read as cases, 4 as controls.
How we read this: Read from 18 sample titles: 18 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7867490 Myeloma_patient_01_T_cells, Gene expression (T1_GEX)
- GSM7867491 Myeloma_patient_01_T_cells, T cell receptor (T1_TCR)
- GSM7867492 Myeloma_patient_01_T_cells, Gene expression (T2_GEX)
- GSM7867493 Myeloma_patient_01_T_cells, T cell receptor (T2_TCR)
- GSM7867494 Myeloma_patient_02_T_cells, Gene expression (T3_GEX)
- GSM7867495 Myeloma_patient_02_T_cells, Surface protein (T3_CSFL)
- GSM7867496 Myeloma_patient_02_T_cells, T cell receptor (T3_TCR)
- GSM7867497 Myeloma_patient_03_T_cells, Gene expression (T4_GEX)
- GSM7867498 Myeloma_patient_03_T_cells, Surface protein (T4_CSFL)
- GSM7867499 Myeloma_patient_03_T_cells, T cell receptor (T4_TCR)
- GSM7867500 Myeloma_patient_04_T_cells, Gene expression (T5_GEX)
- GSM7867501 Myeloma_patient_04_T_cells, T cell receptor (T5_TCR)
- GSM7867502 Healthy_donor_01_T_cells, Gene expression (T42_GEX)
- GSM7867503 Healthy_donor_01_T_cells, T cell receptor (T42_TCR)
- GSM7867504 Healthy_donor_01_T_cells, Gene expression (T43_GEX)
- GSM7867505 Healthy_donor_01_T_cells, T cell receptor (T43_TCR)
- GSM7867506 Myeloma_patient_01_nonBnonT_cells, Gene expression (M1_GEX)
- GSM7867507 Myeloma_patient_01_nonBnonT_cells, Gene expression (M2_GEX)
- GSE274187 CD4+ CAR-T cell exhaustion associated with early relapse of multiple myeloma after BCMA CAR-T cell therapy 23 samples shares car-t, bcma, cd4, exhaustion, multiple, relapse, myeloma, therapy
- GSE304878 Single-cell multi-omics profiling of PBMCs from SLE patients pre- and post-dual-target (BCMA/CD19) CAR-T therapy 30 samples shares car-t, bcma, therapy
- GSE322796 Persistence of mucosal CAR-T cells and inflammatory remodeling in enterocolitis associated with BCMA CAR-T cell therapy 23 samples shares car-t, bcma, therapy
- GSE277428 NKG2D-mediated cytotoxicity of CD4 cytotoxic T cells in multiple myeloma 27 samples shares cd4, multiple, myeloma
- GSE273170 Baseline Immune State and T cell Clonal Kinetics are Associated with Response to CAR-T Therapy in Large B-cell Lymphoma 81 samples shares car-t, therapy
- GSE278119 Clonally expanded effector CD4+ cytotoxic T lymphocytes are associated with severe neurological adverse events after immune checkpoint inhibitor therapy 44 samples shares cd4, therapy
- GSE266486 B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients (human) 21 samples shares car-t, therapy
- GSE314188 Responders to low-dose ATG induce CD4+ T cell exhaustion in type 1 diabetes 514 samples shares cd4, exhaustion
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.