B cell directed CAR-T cell therapy results in activation of CD8+ cytotoxic CAR-negative bystander T cells in both non-human primates and patients (human)
Single-cell RNA-seq · human · 21 samples
- What it is
- Single-cell RNA-seqGene activity measured in thousands of individual cells, so cell types can be told apart. Read from the summary: GEO's own type field only says 'expression profiling by sequencing', so confirm it in the paper.
- Organism
- Homo sapiens (human)
- Samples
- 21 samples: 21 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- B-cell-directed CAR T-cell therapy activates CD8+ cytotoxic CARneg bystander T cells in patients and nonhuman primatesBlood · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE266486_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1107270. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 21 sample titles: 21 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8248013 Pt006_CARPos
- GSM8248014 Pt006_PBMC
- GSM8248015 Pt006_CARNeg
- GSM8248016 Pt007_Product
- GSM8248017 Pt007_CARNeg
- GSM8248018 Pt007_CARPos
- GSM8248019 Pt007_PBMC
- GSM8248020 Pt008_Product
- GSM8248021 Pt008_CARNeg
- GSM8248022 Pt008_CARPos
- GSM8248023 Pt008_PBMC
- GSM8248024 Pt009_Product
- GSM8248025 Pt009_PBMC
- GSM8248026 Pt009_CARNeg
- GSM8248027 Pt010_Product
- GSM8248028 Pt010_PBMC
- GSM8248029 Pt010_CARNeg
- GSM8248030 Pt011_Product
- GSM8248031 Pt011_CARNeg
- GSM8248032 Pt011_CARPos
- GSM8248033 Pt011_PBMC
- GSE225063 Blockade of LAG-3 and PD-1 leads to co-expression of cytotoxic and exhaustion gene modules in CD8+ T cells to promote antitumor immunity 256 samples shares cd8, cytotoxic
- GSE279781 CD137 agonism enhances anti-PD1 induced activation of clonally expanded CD8+ T cells in a neoadjuvant pancreatic cancer clinical trial 30 samples shares cd8, activation
- GSE306620 TCR signaling via NFATc1 constrains IL-15-induced NK-like activation of human memory CD8+ T cells 26 samples shares cd8, activation
- GSE316096 Clonal expansion of cytotoxic CD8+ T cells in lecanemab-associated ARIA 18 samples shares cd8, cytotoxic
- GSE317789 Single-cell and spatial profiling reveal cDC2A-CXCL13+ CD8+ T-epithelial cell crosstalk and cytotoxicity through TNFRSF9 in cutaneous and mucosal lichen planus 42 samples shares cd8, cytotoxic
- GSE285515 NKG2D blockade impairs cytotoxic CD8+ tissue resident memory T cell accumulation and attenuates severity of chronic lung allograft dysfunction after transplantation 15 samples shares cd8, cytotoxic
- GSE235244 Senescent cancer-associated fibroblasts in pancreatic adenocarcinoma suppress CD8+ T cell activation and inhibit response to immune checkpoint therapy [hPDAC] 8 samples shares cd8, activation
- GSE333617 Targeting JAK1/3-STAT1 signaling attenuates cytotoxic T lymphocytes activation for the treatment in Stevens-Johnson syndrome and toxic epidermal necrolysis 26 samples shares activation, cytotoxic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.