Aryl Hydrocarbon Receptor Ligands Present In The Environment Impact Human Trophoblast Cell Development
RNA-seq (gene expression) · human · 18 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 18 samples: 5 conditions, mostly in triplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Aryl Hydrocarbon Receptor Activation Drives 2-Methoxy Estradiol Secretion in Human Trophoblast Stem Cell DevelopmentbioRxiv : the preprint server for biology · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246513_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1033546 and SRA study SRP469097. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 15 samples.
How we read this: 5 replicated groups read from 18 sample titles; they account for 15 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7869974 EVT_V1 EVT_V
- GSM7869975 EVT_V2 EVT_V
- GSM7869976 EVT_V3 EVT_V
- GSM7869977 EVT_TCDD101 EVT_TCDD
- GSM7869978 EVT_TCDD102 EVT_TCDD
- GSM7869979 EVT_TCDD103 EVT_TCDD
- GSM7869980 ST3D_V1 ST3D_V
- GSM7869981 ST3D_V2 ST3D_V
- GSM7869982 ST3D_V3 ST3D_V
- GSM7869983 ST3D_101 (TCDD)
- GSM7869984 ST3D_102 (TCDD)
- GSM7869985 ST3D_103 (TCDD)
- GSM7870018 STEM, Vehicle1 STEM, Vehicle
- GSM7870019 STEM, Vehicle2 STEM, Vehicle
- GSM7870020 STEM, Vehicle3 STEM, Vehicle
- GSM7870021 STEM, TCDD10nM-1 STEM, TCDD10nM
- GSM7870022 STEM, TCDD10nM-2 STEM, TCDD10nM
- GSM7870023 STEM, TCDD10nM-3 STEM, TCDD10nM
- GSE305296 Activation of the aryl hydrocarbon receptor in human melanoma cells enhances cancer cell-intrinsic MHC-II expression 43 samples shares hydrocarbon, receptor, aryl
- GSE262419 Informing Hazard Identification and Risk Characterization of Environmental Chemicals by Combining Transcriptomic and Functional Data from Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes 4558 samples shares environment
- GSE309595 Longitudinal Analysis of Multiple Myeloma: Therapeutic Response and Immune Microenvironment Dynamics in the Context of Tumor Heterogeneity [scRNA-seq] 270 samples shares environment
- GSE222196 Treatment of prostate cancer cell lines with Androgen Receptor and Receptor Tyrosine Kinase inhibitors 246 samples shares receptor
- GSE263733 Single-cell transcriptome analysis reveals subtype-specific clonal evolution and microenvironmental changes in liver metastasis of pancreatic adenocarcinoma and their clinical implications 218 samples shares environment
- GSE314304 IL-11 receptor is a novel target for drug development with pharmacological activity in fibro-inflammatory disease 96 samples shares receptor
- GSE294016 A macrophage-predominant, immunosuppressive immune microenvironment and subtype-specific therapeutic vulnerabilities in advanced salivary gland cancer [bulk RNA-seq] 95 samples shares environment
- GSE237876 Deciphering metastatic route-specific signals and their microenvironment interactions in peritoneal metastasis of gastric cancer 66 samples shares environment
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.