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Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19

GSE246536 Homo sapiens (human) Single-nucleus RNA-seq 17 samples Submitted 2025/01/31 Platform GPL30173Platform GPL24676
At a glance

Single-nucleus RNA-seq · human · 17 samples

What it is
Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
Organism
Homo sapiens (human)
Samples
17 samples: 17 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
Data you can get
A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
Paper
Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19American journal of obstetrics and gynecology · 2025
Summary (written by the submitters)
It is poorly understood how maternal covid-19 results in severe placental disorders. Single nuclei sequencing (sci-rna-seq3) was used to profle transcriptomic changes in the human placenta in response to maternal COVID-19.
Published in
Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19
Keuls RA, Ochsner SA, O'Neill MB et al. · American journal of obstetrics and gynecology 2025 · PMID 40253079 · doi:10.1016/j.ajog.2025.01.028
This dataset
Open GSE246536 in finder → Find more human RNA-seq datasets →
Download · which file do I need?

Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.

1 · Just have a look

Processed table

The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.

Series matrix ↓
2 · Re-analyse it

Supplementary files

The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246536_RAW.tar (it can run to tens of gigabytes).

All supplementary files ↗ Whole study · RAW.tar ↓
3 · Start from the raw reads

Raw sequencing reads

The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.

Raw reads on ENA ↗

What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.

Also filed as BioProject PRJNA1033590 and SRA study SRP469152. Searching any of these in the dataset finder brings you back here.

NCBI GEO page ↗ Paper (PMID 40253079) ↗
Study design
17 samples, each with a distinct title — no replicated groups

Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.

How we read this: Read from 17 sample titles: 17 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.

Samples in this study
Datasets on a similar topic

Search all human RNA-seq datasets in GEO →

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Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.