Single-nucleus RNA seq profiling of term human placenta from maternal obese and lean conditions
Single-nucleus RNA-seq · human · 20 samples
- What it is
- Single-nucleus RNA-seqGene activity measured in individual nuclei (used when whole cells are hard to isolate, for example from frozen tissue).
- Organism
- Homo sapiens (human)
- Samples
- 20 samples: 7 × ms_mo vs 6 × fs_mo vs 4 × fs_lean vs 3 × ms_leanGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Hypoxia in extravillous trophoblasts links maternal obesity and offspring neurobehavioriScience · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE271976_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Single-cell studies usually ship their counts as 10x files (matrix.mtx, barcodes.tsv, features.tsv), an .h5 file, or an .rds / .h5ad object that Seurat or Scanpy can open. Look for those among the supplementary files.
Also filed as BioProject PRJNA1134231 and SRA study SRP519205. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 20 samples.
How we read this: 4 replicated groups read from 20 sample titles; they account for 20 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM8389986 fs_lean_1 fs_lean
- GSM8389987 fs_mo_1 fs_mo
- GSM8389988 ms_mo_1 ms_mo
- GSM8389989 ms_lean_1 ms_lean
- GSM8389990 fs_mo_2 fs_mo
- GSM8389991 fs_lean_2 fs_lean
- GSM8389992 fs_mo_3 fs_mo
- GSM8389993 fs_lean_3 fs_lean
- GSM8389994 ms_mo_2 ms_mo
- GSM8389995 ms_mo_3 ms_mo
- GSM8389996 ms_lean_2 ms_lean
- GSM8389997 ms_mo_4 ms_mo
- GSM8389998 fs_mo_4 fs_mo
- GSM8389999 fs_mo_5 fs_mo
- GSM8390000 fs_lean_4 fs_lean
- GSM8390001 fs_mo_6 fs_mo
- GSM8390002 ms_mo_5 ms_mo
- GSM8390003 ms_lean_3 ms_lean
- GSM8390004 ms_mo_6 ms_mo
- GSM8390005 ms_mo_7 ms_mo
- GSE246536 Single-nucleus transcriptional profiling of the placenta reveals the syncytiotrophoblast stress response to COVID-19 17 samples shares single-nucleus, placenta
- GSE253158 Transcriptional analysis of placenta samples exposed to maternal smoking during pregnancy 79 samples shares placenta, maternal
- GSE298146 SOX4 Mediated Differentiation of Specific T Lymphocyte Subsets at the Maternal-Fetal Interface Contributes to Preterm Labor [RNA-Seq] 34 samples shares maternal, term
- GSE250585 Establishment and comparison of human term placenta-derived trophoblast cells 31 samples shares placenta, term
- GSE287645 Maternal cause of early-onset preeclampsia: excessive endometrial gland-derived apolipoprotein D induces placental ferroptosis and developmental abnormalities 16 samples shares placenta, maternal
- GSE270321 Maternal SARS-CoV-2 impacts fetal placental macrophage programs and placenta-derived microglial models of neurodevelopment 12 samples shares placenta, maternal
- GSE310058 Single-nucleus transcriptomic profiling of human lung tissue in chronic obstructive pulmonary disease (COPD) [snRNA-seq] 149 samples shares single-nucleus
- GSE272342 Transcriptomics profiling of singleton and twin placentas in the absence or presence of preeclampsia. 45 samples shares placenta
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.