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Next Generation Sequencing of circRNAs in bladder cancer derived ITGA6+EVs

GSE246659 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/10/10 Platform GPL24676
Summary
EVs served as crucial mediators preferably achieve their biological effect in recipient cells to create a supportive pre-metastatic niche via delivering distinct biomolecules, among which circular RNAs (circRNAs) with high stability and abundance in tumor derived EVs were under extensive exploration. Moreover, it is well-established that circRNAs play a significant role in BCa lymphatic metastasis. To explore the crucial circRNAs in BCa derived ITGA6+EVs, the ITGA6+EVs from total UM-UC-3-EVs were isolated by affinity capture using anti-ITGA6 magnetic beads and the circRNA expression profile was investigated using next-generation sequencing (NGS).
Published in
Integrin α6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151
Lin Y, Zheng H, Jia L et al. · Journal of extracellular vesicles 2024 · PMID 39329462 · doi:10.1002/jev2.12518
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Also filed as BioProject PRJNA1034078 and SRA study SRP469463. Searching any of these in the dataset finder brings you back here.

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