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Effect of CSPTTK21 on 12 month-old Thy-Tau22 mice, hippocampal samples (ChIP H3K27ac)

GSE246773 Mus musculus Genome binding/occupancy profiling by high throughput sequencing 9 samples Submitted 2025/06/04 Platform GPL21103
Summary
This project aims to identify epigenetic signatures (histone acetylation-related) associated with Tau pathology in hippocampal region of Thy-Tau22 mice in basal conditions and after treatment with CSP-TTK21. For this we performed ChIP for H3K27ac in whole hippocampus of 12 month-old Tau reated with the vehicle CSP or CSP-TTK21, as well as of CSP-treated 12 month-old WT mice.In total we have 6 IPed samples (Biological duplicates were analyzed) and 3 Inputs. Spike-in from drosophila chromatin was added to the samples.
Published in
Hippocampal Astrocyte Morphology Follows an Unexpected Trajectory With Age in a Transgenic Rodent Model of Tauopathy
Augustin E, Vinasco-Sandoval T, Riquelme-Perez M et al. · Glia 2025 · PMID 40119587 · doi:10.1002/glia.70019
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Also filed as BioProject PRJNA1034588 and SRA study SRP469685. Searching any of these in the dataset finder brings you back here.

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