GEO series
Structural Basis for Cytoplasmic Factors Required for Integrator and CPSF Function
GSE246833
Homo sapiens
Expression profiling by high throughput sequencing
24 samples
2024/07/22
GPL24676
Summary
The object of this study (or experiment) was to determine the impact of BRAT1 depletion on the transcriptome during differentiation into neuroprogenitor cells. Two control and two BRAT1 knockout H7-human ESC lines were differentiated for 14 days, total RNA isolated and polyA enriched Click-seq libraries generated. Broad transcriptional misregulation was observed between differentiated knockout and control lines. Specifically, the precocious upregulation of several neurogenesis-driving transcription factors indicates the mistiming of differentiation.
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Paper (PMID 39032490) ↗
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