Structural Basis for Cytoplasmic Factors Required for Integrator and CPSF Function
RNA-seq (gene expression) · human · 24 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 24 samples: 24 samples, each with a distinct title — no replicated groupsGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Cytoplasmic binding partners of the Integrator endonuclease INTS11 and its paralog CPSF73 are required for their nuclear functionMolecular cell · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE246833_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1034958 and SRA study SRP469841. Searching any of these in the dataset finder brings you back here.
Any grouping that defines a comparison lives in the sample characteristics, which GEO records separately from the titles.
How we read this: Read from 24 sample titles: 24 distinct titles with little repetition. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7879930 Day 14 neuroprog., Control Line 1, Biol Rep A
- GSM7879931 Day 14 neuroprog., Control Line 1, Biol Rep B
- GSM7879932 Day 14 neuroprog., Control Line 1, Biol Rep C
- GSM7879933 Day 14 neuroprog., Control Line 2, Biol Rep A
- GSM7879934 Day 14 neuroprog., Control Line 2, Biol Rep B
- GSM7879935 Day 14 neuroprog., Control Line 2, Biol Rep C
- GSM7879936 Day 14 neuroprog., BRAT1 KO 1, Biol Rep A
- GSM7879937 Day 14 neuroprog., BRAT1 KO 1, Biol Rep B
- GSM7879938 Day 14 neuroprog., BRAT1 KO 1, Biol Rep C
- GSM7879939 Day 14 neuroprog., BRAT1 KO 2, Biol Rep A
- GSM7879940 Day 14 neuroprog., BRAT1 KO 2, Biol Rep B
- GSM7879941 Day 14 neuroprog., BRAT1 KO 2, Biol Rep C
- GSM7879942 Day 0 ESC, Control Line 1, Biol Rep A
- GSM7879943 Day 0 ESC, Control Line 1, Biol Rep B
- GSM7879944 Day 0 ESC, Control Line 1, Biol Rep C
- GSM7879945 Day 0 ESC, Control Line 2, Biol Rep A
- GSM7879946 Day 0 ESC, Control Line 2, Biol Rep B
- GSM7879947 Day 0 ESC, Control Line 2, Biol Rep C
- GSM7879948 Day 0 ESC, BRAT1 KO 1, Biol Rep A
- GSM7879949 Day 0 ESC, BRAT1 KO 1, Biol Rep B
- GSM7879950 Day 0 ESC, BRAT1 KO 1, Biol Rep C
- GSM7879951 Day 0 ESC, BRAT1 KO 2, Biol Rep A
- GSM7879952 Day 0 ESC, BRAT1 KO 2, Biol Rep B
- GSM7879953 Day 0 ESC, BRAT1 KO 2, Biol Rep C
- GSE304680 Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription [RNA-seq] 25 samples shares structural, basis
- GSE330399 Molecular and Structural Basis of Pan-Resistance to BTK Inhibitors and Degraders 100 samples shares structural, basis
- GSE302002 Structural Basis of DNA-Dependent Coactivator Recruitment by the Tuft Cell Master Regulator POU2F3 [RNA-seq] 18 samples shares structural, basis
- GSE285023 Biochemical Profiling and Structural Basis of ADAR1-Mediated RNA Editing 10 samples shares structural, basis
- GSE304789 Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription 38 samples shares structural, basis
- GSE297001 The small but versatile DSS1 protein is required for proper Integrator–PP2A function [ChIP-seq] 10 samples shares integrator, required
- GSE297000 The small but versatile DSS1 protein is required for proper Integrator–PP2A function [CUT&Tag] 10 samples shares integrator, required
- GSE304681 Structural and functional basis of PU.1-BAF interaction enables targeting of lineage-specific transcription [ChIP-seq] 7 samples shares structural, basis
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.