GEO series
Biochemical Profiling and Structural Basis of ADAR1-Mediated RNA Editing
GSE285023
Homo sapiens
Expression profiling by high throughput sequencing
10 samples
2025/03/31
GPL21697
Summary
ADAR1-mediated RNA editing suppresses the immunostimulatory potential of endogenous RNA. Deficiency in ADAR1 triggers inflammatory responses; however, the underlying mechanisms remain unclear. In this study, we overexpressed wild-type ADAR1 (ADAR1 WT) and various disease-associated ADAR1 variants in 293T cells to examine transcriptomic RNA editing events. We further compared how disease-associated ADAR1 variants fail to edit specific RNA substrates, potentially contributing to the activation of inflammatory pathways.
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