GEO series
Transcriptional changes of tumoral dendritic cells with tumor progession
GSE246849
Mus musculus
Expression profiling by high throughput sequencing
12 samples
2024/12/02
GPL24247
Summary
Dendritic cells (DCs) play important role of orchestrating anti-tumor immune responses both in tumor context. Following tumor progession, DCs were dysfunctioned by chaotic tumor microenvironment. To understand the change in the molecular level, we purfied conventional DCs from tumor at early stage (day 7 and around 200mm3) or late stage (day14 and larger than 600mm3) and sent for sequencing. Additonally, we would like to understand how pde5 deletion affects DCs function.
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Paper (PMID 40562926) ↗
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