PSPC1 selectively controls tumorigenesis and oncogenic transcription in acute myeloid leukemia
ChIP-seq / ATAC-seq (genome binding and open chromatin) · human · 17 samples
- What it is
- ChIP-seq / ATAC-seq (genome binding and open chromatin)Where proteins bind the genome, or which regions are open and active.
- Organism
- Homo sapiens (human)
- Topic
- Acute myeloid leukemiaThis series is part of our curated briefing on it.
- Samples
- 17 samples: 6 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- PSPC1 exerts an oncogenic role in AML by regulating a leukemic transcription program in cooperation with PU.1Cell stem cell · 2025
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247302_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for peak files (.bed, .narrowPeak) and signal tracks (.bigWig) among the supplementary files; the raw reads are on ENA.
Also filed as BioProject PRJNA1037071 and SRA study SRP470830. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 6 replicated groups read from 17 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7886833 OCIAML5_PSPC1_ChIP
- GSM7886834 OCIAML5_PU1_ChIP_shCTL
- GSM7886835 OCIAML5_PU1_ChIP_shPSPC1
- GSM7886836 OCIAML6_RNAPOII_Ser5
- GSM7886837 OCIAML5_IgG
- GSM7886838 For_PSPC1_MOLM13_shCTL_1 For_PSPC1_MOLM13_shCTL
- GSM7886839 For_PSPC1_MOLM13_shCTL_2 For_PSPC1_MOLM13_shCTL
- GSM7886840 For_PSPC1_MOLM13_shPSPC1_1 For_PSPC1_MOLM13_shPSPC1
- GSM7886841 For_PSPC1_MOLM13_shPSPC1_2 For_PSPC1_MOLM13_shPSPC1
- GSM7886842 For_PSPC1_OCIAML5_shCTL_1 For_PSPC1_OCIAML5_shCTL
- GSM7886843 For_PSPC1_OCIAML5_shCTL_2 For_PSPC1_OCIAML5_shCTL
- GSM7886844 For_PSPC1_OCIAML5_shPSPC1_1 For_PSPC1_OCIAML5_shPSP…
- GSM7886845 For_PSPC1_OCIAML5_shPSPC1_2 For_PSPC1_OCIAML5_shPSP…
- GSM7886846 For_PU.1_OCIAML5_shCTL_1 For_PU.1_OCIAML5_shCTL
- GSM7886847 For_PU.1_OCIAML5_shCTL_2 For_PU.1_OCIAML5_shCTL
- GSM7886848 For_PU.1_OCIAML5_shPU1_1 For_PU.1_OCIAML5_shPU1
- GSM7886849 For_PU.1_OCIAML5_shPU1_2 For_PU.1_OCIAML5_shPU1
- GSE137851 The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia 387 samples same disease briefing · shares transcription, leukemia, myeloid
- GSE270185 Repurposing CD19-directed immunotherapies for pediatric t(8;21) acute myeloid leukemia 249 samples same disease briefing · shares leukemia, myeloid
- GSE137574 Kevetrin induces apoptosis in TP53 wild-type and mutant acute myeloid leukemia cells 24 samples same disease briefing · shares leukemia, myeloid
- GSE303795 Halofuginone exerts broad-spectrum cytotoxic effects by regulating p-eIF2α-S100A8/A9-calcium signaling, inhibiting global protein synthesis, and reversing the resistance of idarubicin in acute myeloid leukemia 6 samples same disease briefing · shares leukemia, myeloid
- GSE129437 Genome-wde mapping of BRD9 binding sites and gene expression changes upon BRD9 knockdown 6 samples same disease briefing
- GSE122515 Bonn Dataset 3 of meta-analysis on AML classification, RNAseq dataset 0 samples same disease briefing
- GSE273326 A trimeric USP11-USP7-TCEAL1 complex stabilizes paused RNAPII to sustain oncogenic transcription 63 samples shares transcription, oncogenic
- GSE293334 Allelic topological centering by transcription factors drives oncogenic multi-enhancer transcriptional regulation [ChIP-seq] 60 samples shares transcription, oncogenic
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.