miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male mice
RNA-seq (gene expression) · mouse · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Mus musculus (mouse)
- Samples
- 12 samples: 6 × Wild type animal vs 6 × miR379-410 cKO animalGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- miRNA-mediated inhibition of an actomyosin network in hippocampal pyramidal neurons restricts sociability in adult male miceCell reports · 2024
Read the full summary ↓
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247439_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1037562 and SRA study SRP471131. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 2 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7889973 Wild type animal 1 Wild type animal
- GSM7889974 Wild type animal 2 Wild type animal
- GSM7889975 Wild type animal 3 Wild type animal
- GSM7889976 Wild type animal 4 Wild type animal
- GSM7889977 Wild type animal 5 Wild type animal
- GSM7889978 Wild type animal 6 Wild type animal
- GSM7889979 miR379-410 cKO animal 1 miR379-410 cKO animal
- GSM7889980 miR379-410 cKO animal 2 miR379-410 cKO animal
- GSM7889981 miR379-410 cKO animal 3 miR379-410 cKO animal
- GSM7889982 miR379-410 cKO animal 4 miR379-410 cKO animal
- GSM7889983 miR379-410 cKO animal 5 miR379-410 cKO animal
- GSM7889984 miR379-410 cKO animal 6 miR379-410 cKO animal
- GSE334363 PDE5a Inhibition Restricts Cancer Metastasis by Disrupting NPC1-Mediated Cholesterol Trafficking Through a Non-canonical cGMP-Dependent Pathway 18 samples shares inhibition, restricts
- GSE266662 DLK-dependent protein network regulates hippocampal glutamatergic neuron degeneration 14 samples shares hippocampal, network
- GSE292261 A dynamic gene regulatory code drives synaptic development of hippocampal granule cells [SS2] 576 samples shares hippocampal
- GSE318028 Pharmacological inhibition of FKBP51 mitigates early life adversity-induced social deficits 246 samples shares inhibition
- GSE293819 Monitoring systemic immune responses to checkpoint inhibition in breast cancer reveals host responses and mechanisms of resistance 142 samples shares inhibition
- GSE312790 Aberrant mRNA Splicing and Impaired Hippocampal Neurogenesis in Grin2b Mutant Mice 133 samples shares hippocampal
- GSE285890 Sex and genotype affect mouse hippocampal gene expression in response to blast-induced traumatic brain injury 96 samples shares hippocampal
- GSE307181 Sex specific correction of maternal inflammation-induced behavioral abnormalities by the inhibition of colony-stimulating factor 1 receptor 96 samples shares inhibition
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.