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MUC1-C REGULATES NEAT1 lncRNA EXPRESSION AND PARASPECKLE FORMATION IN CANCER STEM CELLS

GSE247441 Homo sapiens Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/08 Platform GPL24676
Summary
MUC1-C subunit plays an essential role in regulating NEAT1 expression. MUC1-C activates the NEAT1 gene with induction of the NEAT1_1 and NEAT1_2 isoforms by NF-kB- and MYC-mediated mechanisms. MUC1-C/MYC signaling also induces expression of the SFPQ, NONO and FUS RNA binding proteins (RBPs) that associate with NEAT1_2 and are necessary for paraspeckle formation.
Published in
MUC1-C regulates NEAT1 lncRNA expression and paraspeckle formation in cancer progression
Bhattacharya A, Wang K, Penailillo J et al. · Oncogene 2024 · PMID 38802648 · doi:10.1038/s41388-024-03068-3
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Also filed as BioProject PRJNA1037566 and SRA study SRP471112. Searching any of these in the dataset finder brings you back here.

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