Transcriptomic characterization of circulating neutrophils isolated from patients with metabolic dysfunction-associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH).
RNA-seq (gene expression) · human · 12 samples
- What it is
- RNA-seq (gene expression)Gene activity measured by sequencing. The summary does not mention single-cell work, so this is most likely bulk: one average per sample, the usual starting point for comparing groups.
- Organism
- Homo sapiens (human)
- Samples
- 12 samples: 5 × Normal vs 4 × Advanced vs 3 × MildGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Circulating Neutrophil Profiles Undergo a Dynamic Shift during Metabolic Dysfunction-Associated Steatohepatitis (MASH) ProgressionBiomedicines · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE247467_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: For RNA-seq the counts are usually a table among the supplementary files (look for 'counts', 'expression', 'FPKM' or 'TPM' in the file name). The series matrix of a sequencing study is sometimes nearly empty.
Also filed as BioProject PRJNA1038739 and SRA study SRP471237. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 12 samples.
How we read this: 3 replicated groups read from 12 sample titles; they account for 12 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7890424 Advanced_1 Advanced
- GSM7890425 Advanced_2 Advanced
- GSM7890426 Advanced_3 Advanced
- GSM7890427 Advanced_4 Advanced
- GSM7890428 Mild_1 Mild
- GSM7890429 Mild_2 Mild
- GSM7890430 Mild_3 Mild
- GSM7890431 Normal_1 Normal
- GSM7890432 Normal_2 Normal
- GSM7890433 Normal_3 Normal
- GSM7890434 Normal_4 Normal
- GSM7890435 Normal_5 Normal
- GSE255312 Spatial transcriptomics landscape for liver from patients with metabolic dysfunction-associated steatohepatitis (MASH) 72 samples shares mash, dysfunction-associated, steatohepatitis
- GSE308064 PAD4⁺ Neutrophils Promote Hepatic Stellate Cell Activation and Accelerate MASH Fibrosis Progression via NETs-DNA/TAOK1/MAPK Pathways 6 samples shares mash, neutrophils
- GSE289173 Single-cell eQTL analysis identifies genetic variation underlying metabolic dysfunction-associated steatohepatitis 48 samples shares dysfunction-associated, steatohepatitis
- GSE274114 Metabolic dysfunction-associated steatohepatitis reduces interferon and macrophage liver gene signatures in chronic HBV patients 39 samples shares dysfunction-associated, steatohepatitis
- GSE326385 Fucoxanthin ameliorates metabolic dysfunction-associated steatohepatitis via suppression of CD36-driven fatty acid uptake 18 samples shares dysfunction-associated, steatohepatitis
- GSE66676 Nonalcoholic steatohepatitis in adolescents undergoing bariatric surgery 67 samples shares steatohepatitis, nonalcoholic
- GSE267195 Single-cell landscape of peripheral immune cells in MAFLD/MASH 68 samples shares mash
- GSE268518 Duodenal-derived organoids from MASH patients exhibit altered digestive homeostasis. 39 samples shares mash
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.