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Effect of systemic depletion of glutamine via PEGylated glutaminase on CT26 tumor tissue.

GSE247472 Mus musculus Expression profiling by high throughput sequencing 6 samples Submitted 2024/04/16 Platform GPL17021
Summary
Proliferating cancer cells are addicted to glutamine for biomass synthesis and energy generation. We here enzymatically deplete circulating glutamine in mice and report how cancer cells adapt to low circulating glutamine and document immunological changes in the tumor microenvironment (TME) upon glutamine depletion in CT26 tumor model. We show that cancer cells adapt to low glutamine by diverting intracellular glutamine flux to nucleotide synthesis and downregulating global translation. Through immune cell deconvolution and GSEA, we show that systemic glutamine depletion is immunsosuppressive and marked by accumulaton of PMN-MDSC in the TME.
Published in
Enzymatic depletion of circulating glutamine is immunosuppressive in cancers
Kumar M, Leekha A, Nandy S et al. · iScience 2024 · PMID 38770139 · doi:10.1016/j.isci.2024.109817
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Also filed as BioProject PRJNA1038746 and SRA study SRP471244. Searching any of these in the dataset finder brings you back here.

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