GEO series
RNASeq, multiome, and genomic profiling of hematopoietic progenitors and B cells from mice with a point mutation in MYC [CUT&RUN]
GSE247612
Mus musculus
Genome binding/occupancy profiling by high throughput sequencing
38 samples
2024/04/03
GPL17021
Summary
We generated mice with a mutation at threonine 58 of MYC in the mouse germline (T58A mutant). These mice ultimately develop AML or B cell lymphomas. We profiled changes in gene expression and genomic occupation of MYC in single cells of sorted, immature bone marrow progenitor cells, mature (spleen derived) and immature (marrow derived) B cells. B cells were stimulated with LPS and IL7, respectively.
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Paper (PMID 37961183) ↗
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