GEO series
RNA-seq analysis of human iPSC derived Hepatocyte organoids (iHOs), 2D-iPS-Heps, iPS-HPCs, iPSCs, and other iPSC derived organoids cultured in woBA medium and fetal organoid medium
GSE248110
Homo sapiens
Expression profiling by high throughput sequencing
30 samples
2025/05/13
GPL28038
Summary
Liver has abundant regenerative capacity, but hepatocytes cannot be cultured long-term in vitro. Activation of FXR signaling induced iHOs with both hepatocyte traits and proliferative potential. To investigate the transcriptomic analysis of iHOs, we performed bulk RNA-seq analysis of organoids in different passages and single cell RNA-seq analysis of iHOs. Compared to 2D-iPS-Heps and organoids in other culture conditions, iHOs have expression profiles more similar to primary human hepatocytes and human fetal liver cells. Single cell RNA-seq revealed iHOs have a fraction that co-expresses hepatocyte markers and proliferation markers.
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