Nitric oxide inhibits Ten-eleven translocation DNA demethylase activity to regulate 5mC and 5hmC across the genome
DNA methylation · human · 28 samples
- What it is
- DNA methylationChemical marks on DNA that help switch genes on or off.
- Organism
- Homo sapiens (human)
- Samples
- 28 samples: 12 conditions, mostly in duplicateGroups are read from the sample names, not from the paper. Check the list below.
- Data you can get
- A processed table (series matrix) and supplementary files from NCBI; the raw sequencing reads from ENA. Which of these hold counts depends on the study, so check the file list.
- Paper
- Nitric oxide inhibits ten-eleven translocation DNA demethylases to regulate 5mC and 5hmC across the genomeResearch square · 2024
Direct links to NCBI and ENA, no account and no request form. Pick by what you want to do: take the small processed table to look, the supplementary files to re-analyse, or the original raw data to start over.
Processed table
The series matrix: one table of values per sample as the submitters processed it. The smallest download, and it opens in Excel or R. Start here to see what the data look like.
Supplementary files
The count tables and other files the authors uploaded. Take only the samples you need, or the whole study as GSE248151_RAW.tar (it can run to tens of gigabytes).
Raw sequencing reads
The original FASTQ files, straight from the sequencer, held at ENA. Large, and you align them yourself, so only choose this if you need to re-process the study from scratch.
What the files usually look like: Look for beta-value tables or raw IDAT files among the supplementary files.
Also filed as BioProject PRJNA1041827 and SRA study SRP472963. Searching any of these in the dataset finder brings you back here.
Supports a between-group comparison across 28 samples.
How we read this: 12 replicated groups read from 28 sample titles; they account for 28 of them. These groups are guessed from the sample names, not taken from the paper, so check them against the sample list below before relying on them.
- GSM7906420 MDA-MB-231 5mC, Control, 10 days, rep1 MDA-MB-231 5mC, Control…
- GSM7906421 MDA-MB-231 5mC5hmC, Control, 10 days, rep1 MDA-MB-231 5mC5hmC, Con…
- GSM7906422 MDA-MB-231 5mC, Control, 10 days, rep2 MDA-MB-231 5mC, Control…
- GSM7906423 MDA-MB-231 5mC5hmC, Control, 10 days, rep2 MDA-MB-231 5mC5hmC, Con…
- GSM7906424 MDA-MB-231 5mC, DETA/NO, 10 days, rep1 MDA-MB-231 5mC, DETA/NO…
- GSM7906425 MDA-MB-231 5mC5hmC, DETA/NO, 10 days, rep1 MDA-MB-231 5mC5hmC, DET…
- GSM7906426 MDA-MB-231 5mC, DETA/NO, 10 days, rep2 MDA-MB-231 5mC, DETA/NO…
- GSM7906427 MDA-MB-231 5mC5hmC, DETA/NO, 10 days, rep2 MDA-MB-231 5mC5hmC, DET…
- GSM7906428 MDA-MB-468 5mC, Control, 10 days, rep1 MDA-MB-468 5mC, Control…
- GSM7906429 MDA-MB-468 5mC5hmC, Control, 10 days, rep1 MDA-MB-468 5mC5hmC, Con…
- GSM7906430 MDA-MB-468 5mC, Control, 10 days, rep2 MDA-MB-468 5mC, Control…
- GSM7906431 MDA-MB-468 5mC5hmC, Control, 10 days, rep2 MDA-MB-468 5mC5hmC, Con…
- GSM7906432 MDA-MB-468 5mC, DETA/NO, 10 days, rep1 MDA-MB-468 5mC, DETA/NO…
- GSM7906433 MDA-MB-468 5mC5hmC, DETA/NO, 10 days, rep1 MDA-MB-468 5mC5hmC, DET…
- GSM7906434 MDA-MB-468 5mC, DETA/NO, 10 days, rep2 MDA-MB-468 5mC, DETA/NO…
- GSM7906435 MDA-MB-468 5mC5hmC, DETA/NO, 10 days, rep2 MDA-MB-468 5mC5hmC, DET…
- GSM7906436 MDA-MB-231, Control, 10 days, rep1 MDA-MB-231, Control, 10…
- GSM7906437 MDA-MB-231, Control, 10 days, rep2 MDA-MB-231, Control, 10…
- GSM7906438 MDA-MB-231, Control, 10 days, rep3 MDA-MB-231, Control, 10…
- GSM7906439 MDA-MB-231, DETA/NO, 10 days, rep1 MDA-MB-231, DETA/NO, 10…
- GSM7906440 MDA-MB-231, DETA/NO, 10 days, rep2 MDA-MB-231, DETA/NO, 10…
- GSM7906441 MDA-MB-231, DETA/NO, 10 days, rep3 MDA-MB-231, DETA/NO, 10…
- GSM7906442 MDA-MB-468, Control, 10 days, rep1 MDA-MB-468, Control, 10…
- GSM7906443 MDA-MB-468, Control, 10 days, rep2 MDA-MB-468, Control, 10…
- GSM7906444 MDA-MB-468, Control, 10 days, rep3 MDA-MB-468, Control, 10…
- GSM7906445 MDA-MB-468, DETA/NO, 10 days, rep1 MDA-MB-468, DETA/NO, 10…
- GSM7906446 MDA-MB-468, DETA/NO, 10 days, rep2 MDA-MB-468, DETA/NO, 10…
- GSM7906447 MDA-MB-468, DETA/NO, 10 days, rep3 MDA-MB-468, DETA/NO, 10…
- GSE248150 Nitric oxide inhibits ten-eleven translocation DNA demethylase activity to regulate 5mC and 5hmC across the genome [RNA-seq] 12 samples shares 5hmc, translocation, demethylase, ten-eleven, inhibits, activity, regulate, nitric
- GSE236272 Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation 20 samples shares demethylase, inhibits, activity, regulate, nitric
- GSE236270 Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-231-RNASeq] 6 samples shares demethylase, inhibits, activity, regulate, nitric
- GSE236269 Nitric oxide inhibits FTO demethylase activity to regulate N6-methyladenosine mRNA methylation [MDA-MB-468-RNASeq] 6 samples shares demethylase, inhibits, activity, regulate, nitric
- GSE300200 The Lysine Demethylase Kdm4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma 26 samples shares demethylase, activity, regulate
- GSE300199 The Lysine Demethylase Kdm4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma [ChIP-seq] 14 samples shares demethylase, activity, regulate
- GSE300083 The Lysine Demethylase Kdm4C is an Oncogenic Driver and Regulates ERK Activity in KRAS Mutant Pancreatic Ductal Adenocarcinoma [RNA-Seq] 12 samples shares demethylase, activity, regulate
- GSE194281 The KDM1A and KDM7A lysine demethylases cooperate to regulate androgen receptor function in prostate cancer cells 30 samples shares demethylase, regulate
Metadata from NCBI GEO, cached and refreshed periodically — the NCBI page above is authoritative. Downloads link straight to NCBI/ENA; nothing is proxied through BioTransfer.